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Selamectin Chemical group: Macrocyclic lactone Trade name: Revolution Mode of action: Binds to glutamate gated chloride channels in the parasites’ nervous system, causing them to open. Pharmacokinetics: Absorbed through the skin and distributed via the blood. Concentrates in sebaceous glands. Active concentrations are found in the plasma for at least 30 days. Most excreted unmetabolized in the feces, and a small amount in the urine. Dose: 6 mg/kg (topical) Use in animals over 6 weeks of age. Toxicity: Cats: 60 mg/kg (10 X dose) produced no adverse reactions when given to kittens (initially 6 wks old) for 7 monthly treatments. 18 mg/kg (3 X dose) produced no effect on reproduction in females or males and no problems in heartworm positive cats. Orally a 6 mg/kg dose caused 2 of 6 cats to vomit (probably due to the alcohol carrier). (See: Krautmann, MJ, et al. 2000. Safety of Selamectin in Cats. Vet. Parasitol. 91:393-403.) Dogs: 60 mg/kg (10 X dose) produced no adverse reactions when give to puppies (initially 6 wks old) for 7 monthly treatments. 18 mg/kg (3 X dose) produced no effect on reproduction in females or males and no problems in heartworm positive dogs (but it did reduce the levels of microfilaria to nil by the 3rd monthly treatment). 3 monthly doses of 30 mg/kg produced no adverse effects in avermectin sensitive collies. (See: Novotny, MJ, et al. 2000. Safety of Selamectin in Dogs. Vet. Parasitol. 91:377-391). Humans: Has a 279 fold safety range. Parasite Targets: hookworms, ascarids, heartworm L3,4, fleas, ticks, scabies, Otodectes |
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