Chemical group: Acylated quinoline-pyrazine
Mode of action: Modulates cell membrane permeability (calcium dependent), leads to a disintegration of the tapeworm’s tegument.
Pharmacokinetics: Rapidly absorbed from the gut, metabolized in the liver, metabolites and unchanged parent compound pass out in the feces.
Dose: Cyclophyllidean Tapeworms: 3 to 5 mg/kg (PO or SC)
Pseudopyllidean Tapeworms: 35 mg/kg (SC)3
Intestinal Trematodes: 30 mg/kg (PO)
Lung flukes in dogs: 25 mg/kg, TID for 2 days. 4
Toxicity: LD50 in rats is between 2000 and 3000 mg/kg. No clinical effects seen in dogs or cats dosed with 100 mg/kg.
Parasite Targets: Tapeworms and trematodes.
© University of Pennsylvania 2004
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