Moxidectin

Chemical group: Macrocyclic lactone

Trade name: ProHeart, ProHeart6

Mode of action: Probably works like other macrocyclic lactones and opens chloride channels in the nerve cells, causing paralysis.

Pharmacokinetics:  Dog: ProHeart6: Peak blood levels by 7 to 14 days post-injection, by 6 months post-injection little drug remains in the dog.

Dose: Dog: ProHeart:  3 µg/kg, once a month, (PO). For use in dogs over 8 weeks of age.

                    ProHeart6: 0.17mg/kg, [microspheres] once every 6 months (SQ)  For use in dogs over 6 months of age.

Toxicity: Dog: Safe at up to 5 to 10 times the recommended dose, in a collie given 30 times the recommended dose, ataxia, salivation and mild depression were seen.

Parasite Targets: Dirofilaria immitis L₃ and young L₄. ProHeart6 will kill hookworms for up to 2 weeks after it is injected.

© University of Pennsylvania  2004

Comments or Questions please contact:  Dr. Nolan at: