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Milbemycin Oxime Chemical group: Macrocyclic lactone Trade names: Interceptor, Sentinel* Mode of action: Opens chloride channels in the nerve cells. Pharmacokinetics: Rapidly absorbed from the gut. Cleared from blood by 120 hours. Dose: 0.5 mg/kg (PO). Use in dogs over 4 weeks of age (Interceptor). Toxicity: Toxic dose is above 10 mg/kg. Parasite Targets: Heartworm L4, most nematodes (except adult heartworm and Uncinaria stenocephala), some mites.
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