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    Imidocarb dipropionate

Chemical group: N,N'-bis (3-(4,5-Dihydro-1H-imidazol-2-yl)phenyl) urea

Trade names: IMIZOL

Mode of action: May interfere with polyamine synthesis and function.

Pharmacokinetics: In dogs given an intravenous bolus, the plasma half-life was 207 min and 80% was eliminated in 8 hours. Residues were found mainly in the liver and some in the kidney (it seems to be eliminated through the urine and feces.)

Dose: 6.6 mg/kg, 2 doses, 2 weeks apart, IM or subcutaneous injection.

Toxicity: LD50 in rats was 450 - 1200 mg/kg. Safe in dogs up to 9.9 mg/kg. Causes pain upon injection. Acute toxicity symptoms are consistent with a cholinesterase inhibitor activity.

Parasite Targets: Babesia spp.

 

University of Pennsylvania  2004

Comments or Questions please contact:  Dr. Nolan at: