Fenbendazole

Chemical group:     benzimidazole

Trade names:             Panacur

Mode of action:    Binds to tubulin subunit and interferes with microtubule formation.

Pharmacokinetics:    Poorly absorbed from the gut, most leaves the dog in the feces as fenbendazole, some is metabolized to oxfendazole, probably in liver, and returns to gut in bile. Totally eliminated in 48 hours.

Dose:    50 mg/kg, (PO) SID, for 3 days. For Giardia use for 5 days.  Use in dogs and cats* over 2 weeks of age.

Toxicity:    Toxic dose not found. 500 mg/kg not toxic in a single dose. 250 mg/kg daily for 30 days was not toxic to dogs.

Parasite Targets:    Ascarids, hookworms, Trichuris vulpis, Aelurostrongylus abstrusus, Capillaria sp., Strongyloides sp., Filaroides sp., Taenia sp., Paragonimus kellicotti, Giardia sp.

* Not labeled for cats in the USA.

© University of Pennsylvania  2004

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