Febantel

Chemical group:     Pro-benzimidazole

Trade name:         Drontal Plus*

Mode of action:    Binds to tubulin subunit and interferes with microtubule formation

Pharmacokinetics:    Metabolized in the liver to fenbendazole, oxfendazole, oxfendazole sulphone and at least 7 other metabolites. These may circulate in the blood, but most leave in the bile.

Dose:    25 mg/kg (PO) (Drontal Plus) one dose (3 doses (SID) for Giardia),

Toxicity:    Acute toxicity: LD50 in dogs is over 10,000 mg/kg. Oxfendazole is teratogenic in rats and sheep.

Parasite Targets:    Ascarids, hookworms, Trichuris vulpis., Taenia sp., Giardia sp.

* also contains pyrantel pamoate and praziquantel

© University of Pennsylvania  2004

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