Disophenol Sodium

Chemical group:      Substituted phenol

Trade name:             DNP  - no longer being sold in the United States

Mode of action:    Uncoupler of oxidative phosphorylation 

Pharmacokinetics:    Binds to red blood cells, has a half life in the dog of about 2 weeks.

Dose:    9 mg/kg (SC) in dogs and cats

Toxicity:    Narrow safety range. Blindness, hyperventilation, convulsions, and death are seen with overdoses.

Parasite Targets:    Hookworms, Spirocerca lupi

© University of Pennsylvania  2004

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