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Diethylcarbamazine Chemical group: Piperazine Trade names: Nemacide Mode of action: GABA agonist, causes hyperpolarization of nerve membrane and flaccid paralysis of the nematode, worms are removed by normal peristalsis. Pharmacokinetics: Rapidly absorbed from the gut and excreted in the urine. Elimination is virtually complete by 48 hours. Eliminated through the urine as metabolites. Dose: 11.4 to 22.7 mg/kg (25 to 50 mg/lb), PO. Toxicity: Shock-like reactions in dogs with circulating microfilaria. Vomiting common when given on an empty stomach. LD50 in rodents is 660 mg/kg (mice) and 1380 mg/kg (rats). Parasite Targets: Ascarids
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