Chemical group: Lincosamide antibiotic
Trade name: Antirobe
Mode of action: Binds to ribosomes in
bacteria, in protozoa it is linked to the loss of the 35 kb plastid DNA which is necessary
for production of the vacuole in which the parasites lives. (ME Fichera &
DS Roos. 1997. A plastid organelle as a drug target in apicomplexan parasites.
Pharmacokinetics: Rapidly absorbed from the gut, binds to plasma proteins, partially metabolized in the liver, exits body in urine and bile (feces). It will pass in the milk.
Dose: Dogs: T. gondii: 10 to 40 mg/kg/day (PO) divided TID or QID.
Babesia spp.: 25 mg/kg (PO) divided BID until cured or immunity develops.
Cats: 25 mg/kg divided BID or TID for 28 days (PO)
Toxicity: Dogs tolerated 300 mg/kg daily for up to a year. Dogs receiving 600 mg/kg/day developed anorexia and vomiting.
Parasite Targets: Toxoplasma gondii, Babesia spp.
© University of Pennsylvania 2004
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