Clindamycin

 Chemical group:     Lincosamide antibiotic

Trade name:           Antirobe

Mode of action:      Binds to ribosomes in bacteria, in protozoa it is linked to the loss of the 35 kb plastid DNA which is necessary for production of the vacuole in which the parasites lives.  (ME Fichera & DS Roos. 1997. A plastid organelle as a drug target in apicomplexan parasites. Nature 389:407-409.)
 

Pharmacokinetics:     Rapidly absorbed from the gut, binds to plasma proteins, partially metabolized in the liver, exits body in urine and bile (feces). It will pass in the milk.

Dose:      Dogs:         T. gondii: 10 to 40 mg/kg/day (PO) divided TID or QID.

                               Babesia spp.: 25 mg/kg (PO) divided BID until cured or immunity develops.

Cats:      25 mg/kg divided BID or TID for 28 days (PO)

Toxicity:     Dogs tolerated 300 mg/kg daily for up to a year. Dogs receiving 600 mg/kg/day developed anorexia and vomiting.

Parasite Targets:     Toxoplasma gondii, Babesia spp.

© University of Pennsylvania  2004

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