Cutaneous Lymphosarcoma

This tumor is characterized by an infiltration of neoplastic lymphiod cell into the skin.

Gross Appearance:

Histology:
•Exocytosis of neoplastic cells into the epidermis may be diffuse or multifocal
•Formation of Pautrier microabscesses
•Involvement of adnexal structures
•Invasion of the external root sheath of the hair follicles
•Apocrine glands are frequently affected
•Sebaceous glands are infrequently infiltrated by neoplastic lymphoid cells
•Dermis shows neoplastic lymphoid infiltration
•Replacement of dermal collagen by tumor cells
•Extension into the panniculus adiposus

Clinical Findings:
Clinical Appearance
Patch
Plaque
Tumor
Erythematous
Ulcerative
Papillomatous

Patch Stage
• Uncommon
Plaque Stage
• Solitary or multiple erythematous plaques
Tumor Stage
• May present as solitary intradermal mass
• Multiple tumor nodules are usually found
• Nodules vary in size from several millimeters to several centimeters in diameter
Erythematous Lesions
• Accompanied by alopecia and extensive epidermal scaling
Ulcerative Lesions
• Ulcers are circular
• Extend through the dermis into the subcutis
Papillomatous Lesions
• Have only been seen in one instance of cutaneous lymphosarcoma
Lymph Node Involvement
• Often seen when tumors are present in the skin
• Will develop a hypercalcemia
Sezary-like disease
• Circulating neoplastic lymphocytes are large cells with a convoluted nucleus and a high nucleus to cytoplasmic ratio