Apocrine Ductal Carcinoma
A malignant tumor showing differentiation to apocrine ductal epithelium.
Histology:
•Rare
•Sheets of neoplastic cells show focal lumen formation, lined by a double layer of epithelial cells
•Accumulation of eosinophilic secretion within the lumina
•Cells exhibit nuclear pleomorphism, hyperchromasia and mitotic activity
•Foci of squamous differentiation may be present
•Invasion of surrounding stroma is often seen at the edges
•Lymphatic invasion with nodal metastasis is uncommon
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